TNF and cancer: KEGG pathway analysis revealed that key targets were involved in cancer-related pathways, chemical carcinogenesis, EGFR tyrosine kinase inhibitor resistance, insulin resistance, the relaxin signaling pathway, the HIF-1 signaling pathway, the pI3K-Akt signaling pathway, the FoxO signaling pathway, the ErbB signaling pathway, the estrogen signaling pathway, acute myeloid leukemia, breast cancer, the Rap1 signaling pathway, transcriptional misregulation in cancer, the tumor necrosis factor (TNF) signaling pathway, and Th17 cell differentiation (Figure 2D).