Minoxidil is a selective KATP channel opener targeting Kir6.1/2-Sur2A-B with no action on the Kir6.2-Sur1 subunits, while diazoxide, a KATP channel opener, targeting the pancreatic Kir6.2-Sur1 subunits does not show any breast cancer reactions. The gene discussed is KCNJ11; the disease is breast cancer.