ABCC8 and familial pancreatic carcinoma: Previous clinical literature data have shown that the expression of ABCC8 was found downregulated in pancreatic cancer (Mohelnikova-Duchonova et al., 2013), triple-negative breast cancer (Hlaváč et al., 2013), and lung adenocarcinoma (Wang et al., 2020); the low expression of ABCC8 was associated with poor prognosis in these tumors, while high expression with improved overall survival O.S. In line with these data, ABCC8/Sur1 has been proposed as a new independent prognostic index for glioma patients that had longer survival (Zhou et al., 2020).