The minoxidil-induced overactivation of Kir6.1/2-Sur2A/B subunits in rats provoked a cancer reaction similar to what was observed in some cases of C.S. Omics data reporting the upregulation of the ABCC9, KCNJ11, and KCNJ8 genes in cancers support these conclusions. This evidence concerns the gene KCNJ8 and cancer.