While no missense mutations are reported in KCNJ8, eight, twenty-seven, and five missense mutations related to KCNJ11, ABCC8, and ABCC9, respectively, have been observed in phenotypes prevalently related to well-known diseases such as diabetes mellitus, hyperinsulinemic hypoglycemia, and Brugada syndrome and the recently identified C.S. (Supplementary Table S1). This evidence concerns the gene KCNJ11 and Brugada syndrome.