Phosphorylation of Keap1 causes Nrf2 to migrate to the nucleus when cells it is exposed to neurodegenerative disease-induced oxidative stress (Zhou et al., 2018; Ji et al., 2021; Zong et al., 2021; Mehrbeheshti et al., 2022). The gene discussed is NFE2L2; the disease is neurodegenerative disease.