In vitro experiments have shown that the JBQG drug serum can inhibit the expression of cytokines (IL-6, IL-8, IL-22, IL-23), chemokine proteins and mRNA expression (MMP-1, MMP-2, MMP-3, MMP-9, MMP-13) in rheumatoid arthritis synovial fibroblasts (RA-FLS). This evidence concerns the gene IL22 and rheumatoid arthritis.