This is consistent with the previous studies that showed high (vs. low) doses of A. sinensis treatment enhanced cell survival in cisplatin-induced proximal tubule cell toxicity (Bunel et al., 2015a; Bunel et al., 2015b). Furthermore, A. sinensis exerted a dose-dependent cardioprotective effect on myocardial ischemia rats by regulating the PI3K/Akt pathway (Cao et al., 2020) and on cardiomyoblast cells by inhibiting angiotensin II-induced apoptosis (Huang et al., 2014). This evidence concerns the gene AGT and myocardial ischemia.