Getting a better understanding of the regulation of the natural HPSE1 inhibition by HPSE2 is valuable, since HPSE1 plays a prominent role in the manifestation of various glomerular diseases (van der Vlag and Buijsers, 2020; Rabelink et al., 2017; van den Hoven et al., 2007). This evidence concerns the gene HPSE and glomerular disorder.