There are 12 variables significantly associated with severe chemotherapy-related toxicity: cancer type (non-GI, p < 0.001), number of chemotherapy agents (polychemotherapy, p = 0.042), chemotherapy dose (standard dose, p = 0.078), BMI (<20 kg/m2, p < 0.001), KPS (<90%, p < 0.001), ECOG (>1, p = 0.036), comorbidity (CCI≥4, p = 0.002), low white blood cell (<4 × 109/L, p < 0.001), low neutrophils (<2×109/L, p < 0.001), anemia (hemoglobin<110 g/L, p < 0.001), low platelets (<100×109/L, p < 0.001), hypoalbuminemia (albumin<35 g/L, p < 0.001), and low creatine level (<59 μmol/L, p < 0.001). The gene discussed is ALB; the disease is anemia.