HLA-A and toxic epidermal necrolysis: Hama et al. (2022) reported that the frequency of HLA-A*32:01 is 6.8% in European population and 20% of whom developed vancomycin-induced DRESS. Unlike drug-induced SJS/TEN and DRESS, there has not been a definite link between drug-induced AGEP and specific HLA genotypes (Owen and Jones, 2021). Individuals with IL-36 RA deficiency seems to being subjected to drug-induced AGEP. However, it is still unclear how IL-36 RA deficiency leads to AGEP (Gabay and Towne, 2015).