CD8A and hepatocellular carcinoma: To induce an adaptive immune response in HCC, activated dendritic cells present process antigens that bind to class II Human Leukocyte Antigen molecules to naïve CD4+T cells, and then provoke the differentiation of CD4+ T cells into type 1 T helper cells, leading to differentiation into effector CD8+ cytotoxic T lymphocytes (Cariani and Missale, 2019).