AKT1 and breast cancer: The KEGG pathway enrichment analysis results further showed that the upregulated DEGs were significantly enriched in neutrophil extracellular trap formation, alcoholic liver disease, and neuroactive ligand-receptor interaction, whereas the downregulated DEGs were significantly enriched in malignancy-related pathways, including pathways in cancer, BC, PI3K-Akt signaling pathway, MAPK signaling pathway, and focal adhesion (Fig. 2D).