Moreover, CRL4DCAF1 was shown to directly bind to LATS1/2 and induce their ubiquitination and degradation (Li et al., 2014); thus, upregulated CRL4DCAF1 in NF2-inactivated mesothelioma cells accelerates degradation of LATS1/2 and hence activates YAP. The gene discussed is NF2; the disease is mesothelioma.