NF2 inactivation sensitized cancer cells to ferroptosis because YAP induced the expression of the crucial mediators of ferroptosis such as transferrin receptor 1 (TFRC) and acyl-CoA synthetase long chain family member 4 (ACSL4), suggesting that YAP can act as a tumor suppressor dictating ferroptotic death including mesothelioma (Wu et al., 2019). This evidence concerns the gene ACSL4 and cancer.