Mesothelioma shows frequent somatic alterations in a few tumor suppressor genes, such as BAP1, NF2, CDKN2A/2B, and TP53. Other infrequently but characteristically mutated genes identified in mesothelioma are those involved in histone modifications and RNA processing (Bueno et al., 2016; Hmeljak et al., 2018). The gene discussed is CDKN2A; the disease is mesothelioma.