CCN2 and cancer: In mesothelioma cells, activated YAP/TAZ enhances the transcription of a several important genes to stimulate cancer-promotion and progression, such as those encoding connective tissue growth factor (CTGF) (Fujii et al., 2012), phospholipase-C beta 4 (PLCB4) (Kakiuchi et al., 2016), and interleukin 1β (IL1B) (Matsushita et al., 2019).