CD274 and neoplasm: Our previous study also showed that the infiltration of intraepithelial PD-L1+ tumor-associated macrophages (TAMs), memory T cells (Tmems), regulatory T cells (Tregs), and stromal granzyme B+ activated cytotoxic T cells (aCTLs) had clinical significance and could be used as potential biomarkers to predict prognosis in ESCC patients (Pan et al., 2021).