Our previous study also showed that the infiltration of intraepithelial PD-L1+ tumor-associated macrophages (TAMs), memory T cells (Tmems), regulatory T cells (Tregs), and stromal granzyme B+ activated cytotoxic T cells (aCTLs) had clinical significance and could be used as potential biomarkers to predict prognosis in ESCC patients (Pan et al., 2021). This evidence concerns the gene CD274 and esophageal squamous cell carcinoma.