An animal research indicated that Akkermansia muciniphila (Akk) combining with cisplatin (CDDP) slowed down the growth of tumor volume and improved the changes in tumor pathomorphology and was related to those pathways, including the cytokine-cytokine receptor interaction, Th17 cell differentiation, FOXO, JAK-STAT, and PI3K-Akt signaling pathways (Chen et al., 2020c). Here, AKT1 is linked to neoplasm.