Our data demonstrate a higher incidence of postprocedural CT-ADP >180 seconds in patients with mild PVL compared to those without PVL at discharge (29 vs. 19%) and at 1-month follow-up (28 vs. 19%), suggesting that the defects of VWF HMW-multimers may also be induced by mild PVL. This evidence concerns the gene VWF and periventricular leukomalacia.