(45) found that genes implicated in GP1BA and other formation of tumor cell-platelet microaggregates showed increased expression from hepatic vein to peripheral artery and retains their elevated expression level in peripheral artery and peripheral vein through studies on CTCs of HCC patients; Complement factor H (CFH) is a critical regulatory protein of the complement alternative pathway (AP). This evidence concerns the gene CFH and hepatocellular carcinoma.