GSDMD and infection: Furthermore, intracellular HAdV DNA level in siCASP4+5 vs siNC-transfected and siGSDMD vs siNC-transfected dTHP-1 cells are comparable at different timepoints post-infection (Supplementary Figures 2C, D), indicating that silencing of caspase-4/5 and GSDMD did not affect the HAdV replication.