In terms of expression level, 4 hypoxia-related genes (including POSTN, BMP4, MXRA5 and LBH) were significantly upregulated in clinical GC samples compared with the normal group, while APOD expression decreased in GC samples (TCGA cohort-Figure 4A; clinical samples-Figure 4B). The gene discussed is MXRA5; the disease is gastric cancer.