Clinical data including the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) and its international normalized ratio (INR), as well as multivariable prognostic models based on clinical data obtained from the Chronic Liver Failure Consortium (CLIF-C) ACLF (8), the Chinese Group on the Study of Severe Hepatitis B-ACLF (COSSH-ACLF) criteria (9), the model for end-stage liver disease (MELD) (10), and MELD-Na (11), are useful for the assessment of disease severity and prognosis to guide treatment; however, there are some limitations. Here, GPT is linked to hepatitis B virus infection.