CSF3 and graft versus host disease: LDNs have been found in the peripheral blood of patients with a broad variety of acute and chronic inflammatory diseases, including cancer, HIV-1 infection, SARS-CoV-2 infections, sepsis, graft-versus-host disease (GvHD), trauma, or in healthy donors who received G-CSF treatment for stem cell mobilization, or hematopoietic stem cell transplantation (HSC-T) (112–114).