CD8A and neoplasm: In a study where DCs in CD27-/- mice were manipulated to exhibit constitutive expression of CD70, an ovalbumin (OVA) expressing melanoma model (B16-OVA) was rejected following OVA specific (OT-1) CD8+ T cell transfer and OVA challenge whereas adoptive transfer of CD27-/- OT-1 CD8+ T cells did not elicit protective anti-tumor immunity (90) indicating the contribution of CD27/CD70 pathway to anti-tumor response in this model.