CASP1 and Sepsis: First, the impact of circulating total EVs on endothelial injury is associated with ARDS development during sepsis; second, caspase-1 activity in circulating EVs an associated with ARDS development during sepsis; third, a decline in total EV miR-126-5p levels from day 1 to day 3 is associated with mortality, ARDS and ARF during sepsis.