Indeed, compared to the WT, EGFR mutant cancer cells downregulate the expression of CXCL10, chemoattractant for CD8 T cells, and CCL21, important for the accumulation of NK cells and naïve T cells, and whole tumor extracts revealed a trend toward a lower expression levels of IFNγ (90, 107). This evidence concerns the gene IFNG and neoplasm.