ERVs would then fold in double stranded RNA (dsRNA) that can be sensed in the cytoplasm by toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5) and IRF7 initiating an antiviral-like innate immune cascade ultimately driving interferon (IFN) signaling activation and tumor growth control. This evidence concerns the gene TLR3 and neoplasm.