Using two different classification methods for early AMD (52, 53), Emilsson et al, (2022), identified in a large cohort study of 5457 patients, 15 proteins which had strong association with early-stage AMD including inflammatory regulators CEBPB, CCL1, CXCL17 and CFHR1. This evidence concerns the gene CFHR1 and age-related macular degeneration.