C3 and age-related macular degeneration: The expression of known AMD inflammatory markers secreted from activated microglia/macrophages in retinal degenerations including chemokine Ccl2, inflammasome cleavage enzyme Casp1, and downstream pro-inflammatory cytokine Il-1β were detected in significant levels in the retina from 12h-PD to 24h-PD, in both qRT-PCR and RNA sequencing analyses, with notable inflammasome and complement cluster genes including Casp1, Casp8, C1qa, C3, C4b and C5ar1 peaking in expression at 24h-PD.