Given the well-established crosstalk between PTH and osteocytes on the one hand and the fact that osteocytes act as regulatory cells producing proinflammatory cytokines, among other substances, on the other hand, we expect that decreased PTH levels in hypoparathyroidism lead to decreased levels of proinflammatory cytokines produced by osteocytes, thereby contributing to bone effects seen in conjunction with hypoparathyroidism such as increased bone mineral density due to low bone turnover. This evidence concerns the gene PTH and hypoparathyroidism.