HSP90B2P and neoplasm: Third, the high temperature generated by the photothermal effect of PTA in tumor tissues may harm to neighboring normal tissue cells while killing tumor cells, and the initial high temperature may also induce a large amount of heat shock protein (HSP) expression in the body, increasing the heat resistance of tumor cells and reducing the efficacy of photothermal therapy.150,151 To overcome these problems, some researchers have worked to design mild PTT,152,153 which is expected to kill tumors at a lower temperature.