SIRT1 and metabolic dysfunction-associated steatotic liver disease: Furthermore, vigorous-intensity exercise seems to be more effective for controlling NAFLD because it induces greater activation of hepatic AMPK and its downstream targets, such as restoring SIRT-1 expression in the liver (significantly decreased in a NAFLD model of HFD-fed rats) and leading to upregulation of target molecules associated with fatty acid oxidation and/or mitochondrial biogenesis (Cho et al., 2015).