DNM1L and tauopathy: Inhibition of the action of the GTPase involved in mitochondrial fission dynamin-related protein 1 (DRP1) and reduced levels of mitochondrial metabolic proteins lead to many neurodegenerative diseases through the accumulation of misfolded TAU proteins called “tauopathies.” Normally, TAU is responsible for microtubule attachment and cytoskeleton stability in the brain (Petrozziello et al., 2022).