HIF1 overexpression, oncogene activation (cMyc, K-ras- mTORC1, and Akt), activation of signaling pathways (PI3K/Akt/mTORC1, Ras/Raf/MEK/ERK), an increase in glucose (GLUT) and lactate (MCT4) transporters, and the activation of glycolytic enzymes (HK2, PFK1, ENO1, PKM2, and LDHA) (Wallace, 2005; Choudhury et al., 2020; Han et al., 2021; Mariani et al., 2021; Pluimakers et al., 2021; Shen et al., 2021; Vaupel and Multhoff, 2021; Zhu et al., 2022c) are all part of the metabolic change observed in cancer cells. This evidence concerns the gene PKM and cancer.