PTEN and neoplasm: Furthermore, the functions of tumor suppressors (mutant p53, mutant PTEN, and microRNAs 29, 143, and 144), Sirtuins 3 and 6, and the AMPK signaling pathway (Kumar et al., 2016; Alhebshi et al., 2021; Jazvinšćak Jembrek et al., 2021; Zhang et al., 2022a) are inhibited to prevent cell death and reduce metabolic stress of tumor cells.