DICER1 and cancer: Although DROSHA/DGCR8/DICER1 mutations appear to be infrequent in adult tumors, a recent pan-cancer analysis using The Cancer Genome Atlas and MSK-IMPACT databases reported enrichment of hotspot mutations in DICER1 RNase IIIb and RNase IIIa domains in uterine cancers, including endometrial cancer and uterine sarcoma (63), (64).