For instance, cocktail of antibiotics given to three different amyloid mouse models of AD (APP/PS1, 5xFAD and AppNL-G-F) from early age reduced the amyloid plaque load observed later in life in male mice (Guilherme et al., 2021; Kaur et al., 2021; Mezö et al., 2020; Minter et al., 2016), while no difference has been observed in females. Here, APP is linked to Alzheimer disease.