As we found that LPS and Df stimulation promoted the expression of IL-4, E-selectin, P-selectin, sICAM-1, MIP-1β, and IL-8 in LCs, we speculated that extracellular stimuli might promote the expression of other biomarkers for AD, including MDC, TARC, and MCP1(Fujii et al., 2004; Holm et al., 2021). This evidence concerns the gene CCL22 and Alzheimer disease.