AD is characterized by amyloid-β protein (Aβ) deposition, abnormal phosphorylation aggregation of the microtubule-associated protein tau, neuroinflammation, oxidative stress, and synaptic dysfunction, which are reflected by microglial reaction and increased cytokine production (Braak and Braak, 1991; Heneka et al., 2015; Lepeta et al., 2016; Butterfield and Halliwell, 2019; Bairamian et al., 2022; Paolicelli et al., 2022). This evidence concerns the gene MAPT and Alzheimer disease.