Excess reactive oxygen species (ROS) production led to a caspase-8-mediated decrease in NHLRC2 protein levels, leading to apoptotic cell death in colon cancer cells, suggesting an important role for NHLRC2 in the regulation of ROS-induced apoptosis (Nishi et al., 2017). This evidence concerns the gene NHLRC2 and malignant colon neoplasm.