Based on the literature and novel FINCA patients described in the present study, all the patients with the NHLRC2 gene variants presented with developmental delay, along with variable axial hypotonia, muscle weakness, progressive muscular atrophy (leading to scoliosis), eating problems, poor eye contact, strabismus, seizures, behavioral problems and various types of movement disorders (ataxia, dystonia, cerebgral palsy, tremor and stereotypic hand movements). This evidence concerns the gene NHLRC2 and muscular atrophy.