Altered NHLRC2 or NHLRC2 levels have been detected not only in association with FINCA disease, but also with idiopathic pulmonary fibrosis (IPF) (Boon et al., 2009; Kreus et al., 2022), lung adenocarcinoma (Ye et al., 2019), Parkinson’s disease (van Dijk et al., 2012), Alzheimer’s disease (AD) (Long et al., 2016), and sporadic amyotrophic lateral sclerosis (Andrés-Benito et al., 2020), suggesting that NHLRC2 may indeed play a role in more common pathologies. The gene discussed is NHLRC2; the disease is early-onset autosomal dominant Alzheimer disease.