Here we report three childhood onset cases of anti-LGI1 encephalitis with initiating symptom of seizures, one 11-year-old girl, one 4-year-old boy, and another 17-year-old boy, and the characteristics of clinical manifestation, course of evolution, imaging manifestation and treatment outcomes are summarized, with a review of literature. The gene discussed is LGI1; the disease is encephalitis.