Quercetin, a clear AHR agonist, could shorten the course of chronic DSS colitis in an AHR-dependent manner [309] KAR, a flavonoid derived from Sophora flavescens, is an effective treatment of visceral hypersensitivity in IBS, and it regulates the development of IBS through macrophage-intrinsic AHR [258]. The gene discussed is AHR; the disease is irritable bowel syndrome.