CD274 and neoplasm: For example, the tumor control effect of oral administration of Bifidobacterium in melanoma mice was demonstrated to be the same as that of PD-L1 antibody,214 and the combination of these two methods is highly effective in inhibiting tumor outgrowth.214 In mice fed with western style diet (WSD), an reshaped colonic microbiota composition might cause increased penetrability and reduced formation of mucus layer in the gut.