reuteri can promote the renewal and repair of intestinal epithelium and stimulate the host’s immunity.212 Specifically, L. reuteri was found to convert intraepithelial CD4 + T cells into CD4 + CD8αα + double-positive intraepithelial lymphocytes that relieve inflammatory bowel disease, thus preventing some alimentary tract cancer.213. The gene discussed is CD4; the disease is inflammatory bowel disease.