In acetaminophen-induced liver injury, p53 plays a protective role by regulating the drug-metabolizing enzymes and transporters cytochrome P450s (CYPs), sulfotransferases (SULTs) and mitochondrial ribosomal proteins (MRPs)17, while in cisplatin-induced nephrotoxicity, p53 may mediate tubular cell apoptosis through its regulation of gene transcription18. The gene discussed is TP53; the disease is injury.