TP53 and neoplasm: Massive parallel sequencing was performed on the tumor, analyzing a total of 165 cancer-related genes (additional file 1: Table S1), which identified a pathogenic TP53 gene variant NM_0000546.5(TP53):c.473G > A, p.(Arg158His) (conform ClinVar database https://www.ncbi.nlm.nih.gov/clinvar), at an allelic frequency of 71%.