For the differences of mutation landscape between “stiff tumor” and “soft tumor”, the top ten genes were DNAH9, NYNRIN, PTCHD4, WNK1, ARFGEF1, HRAS, ARHGEF2, MYOM1, ITGB6 and CPS1 (Fig. 3A). The gene discussed is ITGB6; the disease is neoplasm.