Knockdown of the Drosophila homologs for three other genes in this module (BARD1, CCNA2 and CD2AP120) also modulated neuronal dysfunction in Drosophila. Among the cell cycle genes that accumulate in AD neurons, BRCA1 stood out in this module as it interacts with ANLN and BARD1, two genes whose modulation ameliorates neurodegeneration. The gene discussed is BRCA1; the disease is Alzheimer disease.