One such example is the inhibition of JNK activation and JNK-mediated breast cancer cell apoptosis by SGs in recruiting rho-associated, coiled-coil-containing protein kinase 1 (ROCK1) to prevent the phosphorylation of JNK-interacting protein 3 (JIP3) [84, 93]. The gene discussed is MAPK8IP3; the disease is breast cancer.