Instead, missense mutations (F99S (XP/CS) or T119P (TTD) from XPB and p8 mutation L21P (TTD)) localize to the collar structure (Fig. 7e) formed by dynamic communities D (NTE, p52), O (DRD) and K (p8, p52). The gene discussed is ERCC3; the disease is xeroderma pigmentosum.