ClusterProfiler's enrichKEGG function enriches KEGG pathway genes, referring to the human genome, and these genes are enriched in Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Rheumatoid arthritis, Chemokine signaling pathway, TNF signaling pathway, and nuclear factor-κB (NF-κB) signaling pathway (Fig. 4B). This evidence concerns the gene TNF and rheumatoid arthritis.