KEGG enriched 98 signaling pathways (P < 0.05), including cancer, lipids and atherosclerosis, proteoglycans in cancer, fluid shear stress and atherosclerosis, endocrine resistance, and Ras-related protein 1 (Rap1), rat sarcoma (Ras), Phosphoinositide-3 kinase (PI3K)/Akt, chemokine, Mitogen-activated protein kinase (MAPK), Forkhead Box Protein O (FoxO), T-cell receptor, hypoxia-inducible factor-1 (HIF-1), and estrogen signaling pathways (Fig. 6). Here, AKT1 is linked to atherosclerosis.