Since our findings revealed robust IL-10 production in granulocytes with less expression in microglia and monocytes (Fig. 1), we targeted these cell types by generating Mrp8CreIL-10 fl/fl and CX3CR1CreIL-10 fl/fl mice, respectively, to determine the critical source of IL-10 during craniotomy infection, with WT littermates as controls. Here, IL10 is linked to infection.