The critical intracellular and perhaps systemic pathways impacted by Flt-1 and sFlt-1, respectively, that may be involved in elevated hypertension-related mortality risk in carriers of the FLT1 risk genotype, together with the way in which such pathways are ameliorated by carriers of the FLT1 longevity genotypes will require further investigation. This evidence concerns the gene FLT1 and hypertensive disorder.