To elucidate the mechanism by which AIM2 deletion ameliorates cognitive impairment during aging, we further examined the expression of synaptic proteins, and our data showed that the expression levels of PSD‐95 and MAP‐2 were increased in aging AIM2−/− mice compared with aging mice (Figure 2c–e), while there was no difference in the expression of SYN‐1 (Figure S5). Here, MAP2 is linked to Cognitive impairment.