These mice spontaneously develop memory and learning deficiencies (Takeda, 2009) exhibiting Alzheimer's disease‐like features: oxidative stress, increased amyloid precursor protein (APP) and its mRNA, elevated amyloid β (Aβ) levels, phosphorylation of tau, and astrogliosis among others starting at 6 months of age (Butterfield & Poon, 2005; Diaz‐Moreno et al., 2013; Morley et al., 2000; Pallas et al., 2008). Here, APP is linked to Alzheimer disease.