Common surface markers of cancer stem cell include: CD133 (Prominin-1), CD44, stem cell antigen-1 (Sca-1), epithelial/endothelial cell adhesion molecule (EPCAM), sex-determining region Y-box protein 2 (SOX2), etc. Swaminathan et al. [119] developed polymeric nanoparticles targeting CD133 by conjugating an anti-CD133 monoclonal antibody to nanoparticles formulated using poly (D, L lactide-co-glycolide) (PLGA) polymers. Here, PROM1 is linked to cancer.