Li et al. [139] designed ER-targeting pardaxin (FAL) peptides modified ICG conjugated-hollow gold nanospheres (FAL-ICG-HAuNS), together with oxygen-delivering Hb liposome (FAL-Hb lipo) to reverse hypoxia, achieving enhanced anti-tumor efficacy (Figure 10). The gene discussed is GSTM1; the disease is neoplasm.