CRP and lung disorder: Symptom > 7 daysRadiological evidence of lung disease on chest X-ray or CT-scanModerate to severe disease with abnormal gas exchange:(PaO2/FiO2 or PaFi) < 300Or (SaO2/FiO2 or SaFi) < 400 Or ≥2 criteria of the BRESCIA-COVID Respiratory Severity Scale (BCRSSEvidence of a systemic inflammatory response: serum C-reactive protein > 15 mg/dL, D-dimer > 800 ng/mL, ferritin > 1000 mg/dL, or IL-6 levels > 20 pg/mL