This IL-8 production by NPDF can also occur after stimulation with enzymes of the coagulation cascade, such as factor Xa or thrombin, thus indicating that the coagulation system is an inducer of cytokine production in nasal polyps [35] and is probably involved in the accumulation of extracellular fluid required for polyp formation. Here, CXCL8 is linked to nasal cavity polyp.